Malkey Verma

I'm postdoctoral research associate at the MIB, The University of Manchester, Manchester, UK.

MOSES (Microorganism System Biology: Energy and Saccharomyces cerevisiae)

The regulation analysis of MOSES under which we are studying, the extents to which process rates (edges in network terms) are controlled and regulated through metabolism, through signal transduction (e.g. cAMP-PKA), through gene expression (mRNA-transcription and protein-translation) are quantifying using steady state responses of rates, fluxes, concentrations, Vmax’s, enzyme and mRNA abundances, ribosome and RNA polymerase activities to standard perturbations. The extent to which each of these processes is regulated by ATP (ADP, AMP, cAMP) using data obtained from ATP dependencies of all relevant reactions (glycolytic, protein synthesis, mRNA synthesis). Then these dimensions of informations will be integrated into regulation of modules. The extent to which ATP is regulated through ATP/ADP ratio and total adenine nucleotides will be determined, also identifying the processes involved. The regulation of ATP by ATP (internal circulation regulation, the basis for homeostasis at steady state) will be quantified. Regulation due to the standard external perturbations will be quantified in terms of all their components. This analysis will complete the domino systems biology around energy in yeast energetic. Further research includes modelling of glycolysis in Enterococcus faecalis, Sulfolobus solfataricus and Pseudomonas putida.

Experiments and mathematical modeling of biological systems (Saccharomyces cerevisiae, Enterococcus faecalis, Sulfolobus solfataricus and Pseudomonas putida). Model based experimental design and operation.

Dr. Malkhey Verma; MIB, The University of Manchester 131 Princesses Street, Manchester, M1 7DN Phone No. + 44 161 2266 583; Fax No. + 44 161 2266 583 Email: malkhey.verma@manchester.ac.uk