Elon Correa

I'm a research associate at the Laboratory for Bioanalytical Spectroscopy, Manchester Interdisciplinary Biocentre.

“Systems Biology of a genetically engineered Pseudomonas fluorescens with inducible exopolysaccharide production: analysis of the dynamics and robustness of metabolic networks”

With a particular view to exopolysaccharide alginate biosynthesis, this research project systematically explores the dynamics and robustness of metabolic networks in genetically engineered P. fluorescens bacteria. Alginate production is controlled by the addition of external inducers. Network responses from different levels of induction are collected and analyzed. The resulting information is used to accurately model the metabolic network of P. fluorescens.

The model will also applies novel Artificial Intelligence and Evolutionary Computation algorithms to identify gene-knockout targets that affect alginate production. The project applies both a top-down and a bottom-up approach to Systems Biology. The top-down approach involves the analysis of a large quantity of data. The bottom-up approach involves the construction of a genome-scale metabolic model based on the genomic and biochemical information.

Mathematical and statistical modeling of real-world problems. Computational mathematics and computer based problem solving. Statistically and biologically inspired optimization algorithms. Data Mining applied to biomedical problems (bioinformatics). Evolutionary algorithms and artificial intelligence. Computer and network security. Web development.

Elon Correa

Laboratory for Bioanalytical Spectroscopy

Manchester Interdisciplinary Biocentre

University of Manchester

131 Princess Street

Manchester M1 7DN

United Kingdom

Tel: +(44)(0)161-306-5138

Email: elon.correa@manchester.ac.uk